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1

Changes in gene expression and assessment of DNA methylation in primary human hepatocytes and HepG2 cells exposed to the environmental contaminants—Hexabromocyclododecane and 17-β oestradiol

Stanley O. Aniagu, Tim D. Williams, J. Kevin Chipman

Journal:

Year:

2009

Language:

english

File:

PDF, 819 KB

english, 2009

2

Exploiting Drosophila melanogaster in toxicological studies: Analysis of drug uptake and excretion

Emanuela Zaharieva, Kevin Chipman, Matthias Soller

Journal:

Year:

2011

Language:

english

File:

PDF, 77 KB

english, 2011

3

Oxidative and Conjugative Xenobiotic Metabolism in Zebrafish Larvae In Vivo

Jones, Huw S., Panter, Grace H., Hutchinson, Thomas H., Chipman, J. Kevin

Journal:

Year:

2010

Language:

english

File:

PDF, 1.12 MB

english, 2010

4

Safety assessment of the substance [3‐(2,3‐epoxypropoxy)propyl]trimethoxy silane, for use in food contact materials

Silano, Vittorio, Bolognesi, Claudia, Chipman, Kevin, Cravedi, Jean‐Pierre, Engel, Karl‐Heinz, Fowler, Paul, Grob, Konrad, Gürtler, Rainer, Husøy, Trine, Kärenlampi, Sirpa, Mennes, Wim, Milana, Maria

Journal:

Year:

2017

Language:

english

File:

PDF, 526 KB

english, 2017

5

SUPERSEDED: Safety assessment of the substance poly((R)‐3‐hydroxybutyrate‐co‐(R)‐3‐hydroxyhexanoate) for use in food contact materials

Silano, Vittorio, Bolognesi, Claudia, Chipman, Kevin, Cravedi, Jean‐Pierre, Engel, Karl‐Heinz, Fowler, Paul, Franz, Roland, Grob, Konrad, Gürtler, Rainer, Husøy, Trine, Kärenlampi, Sirpa, Mennes, Wim,

Journal:

Year:

2018

File:

PDF, 1.28 MB

2018

6

Risk assessment of chlorinated paraffins in feed and food

Schrenk, Dieter, Bignami, Marguerita, Bodin, Laurent, Chipman, James Kevin, del Mazo, JesÃºs, GraslâKraupp, Bettina, Hogstrand, Christer, Hoogenboom, Laurentius (Ron), Leblanc, JeanâCharles, Nebbi

Journal:

Year:

2020

File:

PDF, 24.70 MB

2020

7

Risk assessment of ochratoxin A in food

Schrenk, Dieter, Bodin, Laurent, Chipman, James Kevin, del Mazo, JesÃºs, GraslâKraupp, Bettina, Hogstrand, Christer, Hoogenboom, Laurentius (Ron), Leblanc, JeanâCharles, Nebbia, Carlo Stefano, Nie

Journal:

Year:

2020

File:

PDF, 15.31 MB

2020

8

Risk assessment of glycoalkaloids in feed and food, in particular in potatoes and potatoâderived products

Schrenk, Dieter, Bignami, Margherita, Bodin, Laurent, Chipman, James Kevin, del Mazo, JesÃºs, Hogstrand, Christer, Hoogenboom, Laurentius (Ron), Leblanc, JeanâCharles, Nebbia, Carlo Stefano, Nielsen

Journal:

Year:

2020

File:

PDF, 19.95 MB

2020

9

Effect of quercetin on the genotoxic potential of cisplatin

Hilary J. Cross, Michael Tilby, J. Kevin Chipman, David R. Ferry, Andreas Gescher

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 569 KB

english, 1996

10

Nmethyl-N-nitrosourea (MNU) induces papillary thyroid tumours which lack ras gene mutations in the hermaphroditic fish Rivulus marmoratus

Jae-Seong Lee, Eun-Ho Park, Joonho Choe, J. Kevin Chipman

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Year:

2000

Language:

english

File:

PDF, 96 KB

english, 2000

11

Stability and optimization of canalicular function in hepatocyte couplets

Dr Joanne C. Wilton, Roger Coleman, David J. Lankester, J. Kevin Chipman

Journal:

Cell Biochemistry and Function

Year:

1993

Language:

english

File:

PDF, 672 KB

english, 1993

12

Does exhaustive exercise result in oxidative stress and associated DNA damage in the chub (Leuciscus cephalus)?

Stanley O. Aniagu, Norman Day, J. Kevin Chipman, Edwin W. Taylor, Patrick J. Butler, Matthew J. Winter

Journal:

Environmental and Molecular Mutagenesis

Year:

2006

Language:

english

File:

PDF, 183 KB

english, 2006

13

Reverse engineering adverse outcome pathways

Edward J. Perkins, J. Kevin Chipman, Stephen Edwards, Tanwir Habib, Francesco Falciani, Ronald Taylor, Graham Van Aggelen, Chris Vulpe, Philipp Antczak, Alexandre Loguinov

Journal:

Environmental Toxicology and Chemistry

Year:

2011

Language:

english

File:

PDF, 6.95 MB

english, 2011

14

Purification of hepatocyte couplets by centrifugal elutriation

Joanne C. Wilton, Delyth E. Williams, Alastair J. Strain, Rosemary A. Parslow, J. Kevin Chipman, Roger Coleman

Journal:

Year:

1991

Language:

english

File:

PDF, 367 KB

english, 1991

15

Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver

Angela Mally, Carmen Graff, Olga Schmal, Sabrina Moro, Carolin Hamberger, Ute M. Schauer, Jens Brück, Sibel Özden, Max Sieber, Ulrich Steger, Dieter Schrenk, Gordon C. Hard, James Kevin Chipman, Wolfg

Journal:

Molecular Nutrition & Food Research

Year:

2010

Language:

english

File:

PDF, 477 KB

english, 2010

16

Supramolecular Iron Cylinder with Unprecedented DNA Binding Is a Potent Cytostatic and Apoptotic Agent without Exhibiting Genotoxicity

Anna C.G. Hotze, Nikolas J. Hodges, Rachel E. Hayden, Carlos Sanchez-Cano, Christopher Paines, Natalia Male, Man-Kit Tse, Chris M. Bunce, J. Kevin Chipman, Michael J. Hannon

Journal:

Chemistry & Biology

Year:

2008

Language:

english

File:

PDF, 983 KB

english, 2008

17

Subcellular compartmentalisation of glutathione: Correlations with parameters of oxidative stress

Richard M. Green, Nikolas J. Hodges, Mark Graham, Michael O’Donovan, J. Kevin Chipman

Journal:

Year:

2006

Language:

english

File:

PDF, 65 KB

english, 2006

18

Uncoupling of the hCYP1B1 catalytic cycle by non-ortho-substituted polychlorinated biphenyl congeners is an indirect mechanism for genotoxicity

Richard M. Green, Mark Graham, Michael R. O’Donovan, J. Kevin Chipman, Nikolas J. Hodges

Journal:

Year:

2007

Language:

english

File:

PDF, 60 KB

english, 2007

19

A quantitative inverse relationship between connexin32 expression and cell proliferation in a rat hepatoma cell line

Gareth Owain Edwards, Shrikant Jondhale, Tao Chen, J. Kevin Chipman

Journal:

Year:

2008

Language:

english

File:

PDF, 641 KB

english, 2008

20

Assessment of an ibuprofen metabolism by zebrafish larvae, using liquid chromatography–mass spectrometry (LC–MS)

Huw S. Jones, Henry T. Trollope, Thomas H. Hutchinson, Grace H. Panter, J. Kevin Chipman

Journal:

Year:

2009

Language:

english

File:

PDF, 392 KB

english, 2009

21

The in vitro efficacy of haemostatic products in the presence of chemical warfare agents—Sulphur mustard (HD) and VX

Charlotte A. Hall, Helen L. Lydon, Christopher H. Dalton, J. Kevin Chipman, Robert P. Chilcott, John S. Graham

Journal:

Year:

2009

Language:

english

File:

PDF, 183 KB

english, 2009

22

Susceptibility of alternative mRNA processing to interference by small molecules; implications for drug design and toxicity

Emanuela Zaharieva, Kevin Chipman, Matthias Soller

Journal:

Year:

2010

Language:

english

File:

PDF, 117 KB

english, 2010

23

Secondary genotoxicity via oxidative stress; a potential mechanism for chloroform?

Emma Beddowes, Stephen Faux, Kevin Chipman

Journal:

Year:

2000

Language:

english

File:

PDF, 102 KB

english, 2000

24

Non-genotoxic carcinogens: early effects on gap junctions, cell proliferation and apoptosis in the rat

Angela Mally, James Kevin Chipman

Journal:

Year:

2002

Language:

english

File:

PDF, 636 KB

english, 2002

25

Chloroform, carbon tetrachloride and glutathione depletion induce secondary genotoxicity in liver cells via oxidative stress

Emma J. Beddowes, Stephen P. Faux, J.Kevin Chipman

Journal:

Year:

2003

Language:

english

File:

PDF, 463 KB

english, 2003

26

Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis

Leda Mirbahai, Timothy D Williams, Huiqing Zhan, Zhiyuan Gong, J Kevin Chipman

Journal:

Year:

2011

Language:

english

File:

PDF, 2.73 MB

english, 2011

27

The response of hepatocytes isolated from phenobarbitone treated mice to mitogenic growth factors

Karin Fletcher, Terry C. Orton, J. Kevin Chipman, Alastair J. Strain

Journal:

Archives of Toxicology

Year:

1997

Language:

english

File:

PDF, 278 KB

english, 1997

28

The rodent nongenotoxic hepatocarcinogen and peroxisome proliferator nafenopin inhibits intercellular communication in rat but not guinea-pig hepatocytes, perturbing S-phase but not apoptosis

Fiona J. Elcock, J. Kevin Chipman, Ruth A. Roberts

Journal:

Archives of Toxicology

Year:

1998

Language:

english

File:

PDF, 254 KB

english, 1998

29

Aggregation and dispersion of silver nanoparticles in exposure media for aquatic toxicity tests

Isabella Römer, Thomas A. White, Mohammed Baalousha, Kevin Chipman, Mark R. Viant, Jamie R. Lead

Journal:

Journal of Chromatography A

Year:

2011

Language:

english

File:

PDF, 807 KB

english, 2011

30

Cytochrome P450s and glucuronosyl transferase in zebrafish larvae

Huw S. Jones, Grace H. Panter, Tom Hutchinson, Kevin J. Chipman

Journal:

Year:

2008

Language:

english

File:

PDF, 60 KB

english, 2008

31

Pregnancy Failure in Laboratory Mice after Multiple Short-term Exposure to Strange Males

CHIPMAN, ROBERT K., HOLT, JOHN A., FOX, KEVIN A.

Journal:

Year:

1966

File:

PDF, 134 KB

1966

32

Induction of dna strand breaks by genotoxicants in the alga Chlamydomonas reinhardtii

Rhiannon M. David, Matthew J. Winter, J. Kevin Chipman

Journal:

Environmental Toxicology and Chemistry

Year:

2009

Language:

english

File:

PDF, 431 KB

english, 2009

33

Furan in heat-treated foods: Formation, exposure, toxicity, and aspects of risk assessment

Sabrina Moro, James Kevin Chipman, Jan-Willem Wegener, Carolin Hamberger, Wolfgang Dekant, Angela Mally

Journal:

Molecular Nutrition & Food Research

Year:

2012

Language:

english

File:

PDF, 761 KB

english, 2012

34

Comparison of the Effects of Redox Cycling and Arylating Quinones on Hepatobiliary Function and Glutathione Homeostasis in Rat Hepatocyte Couplets

Vicki Stone, Roger Coleman, J.Kevin Chipman

Journal:

Toxicology and Applied Pharmacology

Year:

1996

Language:

english

File:

PDF, 114 KB

english, 1996

35

Hepatobiliary function and toxicity in vitro using isolated hepatocyte couplets

Roger Coleman, Joanne C. Wilton, Vicki Stone, J.Kevin Chipman

Journal:

General Pharmacology: The Vascular System

Year:

1995

Language:

english

File:

PDF, 860 KB

english, 1995

36

Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna

Rhiannon M. David, Huw S. Jones, Grace H. Panter, Matthew J. Winter, Thomas H. Hutchinson, J. Kevin Chipman

Journal:

Year:

2012

Language:

english

File:

PDF, 253 KB

english, 2012

37

DNA strand breaks and adducts determined in feral and caged chub (Leuciscus cephalus) exposed to rivers exhibiting variable water quality around Birmingham, UK

Matthew J Winter, Norman Day, Ruth A Hayes, Edwin W Taylor, Patrick J Butler, J.Kevin Chipman

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2004

Language:

english

File:

PDF, 274 KB

english, 2004

38

Past challenges faced: An overview of current educational activities of IUTOX

Erik Dybing, Judith MacGregor, Torbjörn Malmfors, J. Kevin Chipman, Paul Wright

Journal:

Toxicology and Applied Pharmacology

Year:

2005

Language:

english

File:

PDF, 85 KB

english, 2005

39

Gene expression and epigenetic changes by furan in rat liver

Tao Chen, Tim D. Williams, Angela Mally, Carolin Hamberger, Leda Mirbahai, Kevin Hickling, J. Kevin Chipman

Journal:

Year:

2012

Language:

english

File:

PDF, 1020 KB

english, 2012

40

Alternative splicing interference by xenobiotics

Emanuela Zaharieva, J. Kevin Chipman, Matthias Soller

Journal:

Year:

2012

Language:

english

File:

PDF, 765 KB

english, 2012

41

Identification of functional regulatory regions of the connexin32 gene promoter

Joanne M.L Field, Laura A Tate, J.Kevin Chipman, Stephen D Minchin

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

2003

Language:

english

File:

PDF, 256 KB

english, 2003

42

EGF-Induced Receptor Autophosphorylation in Primary Hepatocytes Isolated from Phenobarbitone-Treated Mice

Karin Fletcher, Peter G. Lord, Terry C. Orton, J.Kevin Chipman, Alastair J. Strain

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 106 KB

english, 1999

43

Detection of DNA Strand Breaks in Isolated Mussel (Mytilus edulisL.) Digestive Gland Cells Using the “Comet” Assay

Carys L. Mitchelmore, Claudia Birmelin, David R. Livingstone, J.Kevin Chipman

Journal:

Ecotoxicology and Environmental Safety

Year:

1998

Language:

english

File:

PDF, 429 KB

english, 1998

44

Effects of 1,1-Dichloroethene and of Some of Its Metabolites on the Functional Viability of Mouse Hepatocytes

Alexander Kainz, Hilary Cross, Sally Freeman, Andreas Gescher, J.Kevin Chipman

Journal:

Fundamental and Applied Toxicology

Year:

1993

File:

PDF, 493 KB

1993

45

Effect of oxidative stress and disruption of Ca2+ homeostasis on hepatocyte canalicular function in vitro

Vicki Stone, Gerald D. Johnson, Joanne C. Wilton, Roger Coleman, J.Kevin Chipman

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.38 MB

english, 1994

46

Tissue levels and biomarkers of organic contaminants in feral and caged chub (Leuciscus cephalus) from rivers in the West Midlands, UK

Matthew J. Winter, Frank Verweij, Elisabetta Garofalo, Sergio Ceradini, David J. McKenzie, Mark A. Williams, Edwin W. Taylor, Patrick J. Butler, Ron van der Oost, J. Kevin Chipman

Journal:

Aquatic Toxicology

Year:

2005

Language:

english

File:

PDF, 410 KB

english, 2005

47

Transcriptomic responses of European flounder (Platichthys flesus) to model toxicants

Tim D. Williams, Amer Diab, Fernando Ortega, Victoria S. Sabine, Rita E. Godfrey, Francesco Falciani, J. Kevin Chipman, Stephen G. George

Journal:

Aquatic Toxicology

Year:

2008

Language:

english

File:

PDF, 896 KB

english, 2008

48

Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure ‘biomarker’ signals and induction of inflammatory, innate immune and apoptotic pathways

Michael J. Leaver, Amer Diab, Evridiki Boukouvala, Tim D. Williams, J. Kevin Chipman, Colin F. Moffat, Craig D. Robinson, Stephen G. George

Journal:

Aquatic Toxicology

Year:

2010

Language:

english

File:

PDF, 782 KB

english, 2010

49

Transcriptional responses in neonate and adult Daphnia magna in relation to relative susceptibility to genotoxicants

Rhiannon M. David, Vanja Dakic, Timothy D. Williams, Matthew J. Winter, J. Kevin Chipman

Journal:

Aquatic Toxicology

Year:

2011

Language:

english

File:

PDF, 719 KB

english, 2011

50

Global genomic methylation levels in the liver and gonads of the three-spine stickleback (Gasterosteus aculeatus) after exposure to hexabromocyclododecane and 17-β oestradiol

Stanley O. Aniagu, Tim D. Williams, Yvonne Allen, Ioanna Katsiadaki, J. Kevin Chipman

Journal:

Environment International

Year:

2008

Language:

english

File:

PDF, 436 KB

english, 2008